What is Tablet Manufacturing?
Tablet manufacturing is the design and manufacture of tablets/pills which can be used in various industries, the most popular being pharmaceutical uses. The process is a complex and multi-stage and is closely monitored to ensure the correct amount of drug substance in the right form is delivered at the appropriate time, at the proper rate all while the chemical integrity is kept intact.
What is Granulation in Tablet Manufacturing?
During the manufacturing process there are mainly three ways in which the tablets can be produced and they include: wet granulation, dry granulation and direct compression. The main steps involved in wet granulation are listed and explained below:
- Weighing, milling, and blending of the powders with additives (excipients).
- Preparation of binder solution.
- Mixing of binder solution with powders to form damp mass.
- Screening the dampened powder into granules using a mesh screen.
- Drying of the screened granules.
- Sizing the granulation by dry screening using customized mesh screens.
- Mixing of the dried granules with lubricant.
- Compression of granules into tablets/pills.
The other alternative method of dry granulation can be further categorized into two methods as explained below:
- Slugging – this method of dry granulation involves compressing the powder into a large flat tablet (slug) using a tablet press capable of high stress. Following this, the slugs are broken either manually or milled with the typical milling machines to produce granules of the required size. Lubricant is added to the granules before being compressed into tablets. Example of a pill made this way is Aspirin.
- Roller Compaction – In this method the formulation materials are blended and are passed between high pressure rotating rollers that compress the powder with a range of 1-6 tons of pressure. The resulting material is milled to a uniform homogenous granule size and then mixed with lubricant before being compressed to form a tablet.
What is Blending in Tablet Manufacturing?
Similar to the process that takes place in kitchen blenders, the powders/granules are mixed in a process known as power blending. The blending has a special blender that ensures uniform and homogenous powder mixing by geometric dilution.
What is Compression in Tablet Manufacturing?
This process is also commonly known as direct compression and it involves the direct compression of the powder into tablets without changing the physical nature of the materials. This method is the cheapest means of tablet making and it avoids many problems associated with wet and dry granulation. It should also be noted that tablets manufactured by direct compression are softer than those made by wet and dry granulation.
What is the Reason for Manufacturing a Drug as an Enteric-Coated Tablet?
An enteric-coated tablet is a polymer based coating applied on the surface of the tablet that prevents the disintegration upon reaching the environment of the stomach. This usually works by protecting the drug from the acidity of the stomach or to protect the stomach from the harmful effects of the drug or sometimes to release the drug content.
What is the Role of R & D (Research Development) Assistant in Tablet Manufacturing?
To ensure that the tablet manufacturing process remains up-to-date it is imperative that the research and development department must actively gather and analyse data to gain a picture of what needs to be improved. A research assistant is therefore necessary to assist in analysing the data in liaison with the R&D manager.
How is Medicine Introduced into Tablet Form during Manufacturing?
The medicine or drug content in a tablet finds its way there by a number of methods but the most common method is by direct compression which is used on small scale. This machine accomplishes the introduction of the medicine into the tablet by a feeding granules/powder into a hopper, and into a die cavity. Two punches and a cam system compress the medicine into tablets of the required shape and size.
How to Show Ingredient Loss in Tablet Manufacturing?
Ingredient loss in tablet manufacturing is when the materials constituting the tablet are lost to the environment so much that it makes a measurable difference in weight. To measure the ingredient loss, the tablets
How do I Check the Manufacturing Date of my Tablet?
The first most accurate point is to look for the Date of Manufacture Sticker, this is the most accurate way of working out the age of your tablet. This sticker is added onto the tablet on the day all the components are assembled to make your restraint.
On most tablet box, this is normally located on the back of the back section, but on some containers like boosters may be on the side of the backrest or on the bottom of the seat. See 'Where is the Date of Manufacture located?' for a more detailed list by model.
What is Tablet Manufacturing Cost?
The cost of manufacturing a tablet depends on a number of different factors and it is difficult to put an accurate price tag on it. However, the factors include the method of tablet production, the cost of raw materials, cost of electrical power if large scale, and the number of man-hours if its small scale.
How Multi-layer Tablet Manufacturing can be Improved?
Multi-layer Tablet manufacturing improvement mainly depends on improvement of the machine and process methods. To improve the yield, it is necessary to ensure that the vacuum applied to the die table is balanced. In the case of a three layer press, the feeders can contribute to yield loss. To avoid this, proper setup and adjustment of the feeders must be carried out.